Smart Hybrid Materials (SHMs)
Khashab Research Group
Innovatively Functionalized Nanomaterials for Biomedical, Sensing and Composites Applications

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Enzymatically degradable hybrid organic–inorganic bridged silsesquioxane nanoparticles for in vitro imaging

Fatieiev, Y.; Croissant, J.; Julfakyan, K.; Deng, L.; Anjum, D.H.; Gurinov, A.; Khashab, N.M. Enzymatically Degradable Hybrid Organic-Inorganic Bridged Silsesquioxane Nanoparticles for In-Vitro Imaging. Nanoscale 2015, 7, 15046-15050
 
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Fatieiev, Y.; Croissant, J. G.; Julfakyan, K.; Deng, L.; Anjum, D. H.; Gurinov, A. ; Khashab, N. M.
Enzymatically degradable, bridged silsesquioxane, imaging
2015
We describe biodegradable bridged silsesquioxane (BS) composite nanomaterials with an unusually high organic content (ca. 50%) based on oxamide components mimicking amino acid biocleavable groups. Unlike most bulk BS materials, the design of sub-200 nm nearly monodisperse nanoparticles (NPs) was achieved. These enzymatically degradable BS NPs were further tested as promising imaging nanoprobes.