Smart Hybrid Materials (SHMs)
Khashab Research Group
Innovatively Functionalized Nanomaterials for Biomedical, Sensing and Composites Applications

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Biodegradable Oxamide-Phenylene-Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells

Croissant, J.; Fatieiev, Y.; Julfakyan, K.; Lu, J.; Emwas, A.; Anjum, D.; Omar, H.; Tamanoi, F.; Zink, J.; Khashab, N. M. Biodegradable Oxamide-Phenylene-Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells. Chem. Eur. J. 2016, 22, 14806–14811
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Croissant, J.; Fatieiev, Y.; Julfakyan, K.; Lu, J.; Emwas, A.; Anjum, D.; Omar, H.; Tamanoi, F.; Zink, J.; Khashab, N. M.
Mesoporous organosilica nanoparticles, bridged silsesquioxanes, drug delivery, biodegradable, enzymes
2016
​We describe biodegradable mesoporous hybrid NPs in the presence of proteins, and its application for drug delivery. We synthesized oxamide-phenylene-based mesoporous organosilica nanoparticles (MON) in the absence of silica source which had a remarkably high organic content with a high surface area. Oxamide functions provided biodegradability in the presence of trypsin model proteins. MON displayed exceptionally high payloads of hydrophilic and hydrophobic drugs (up to 84 wt%), and a unique zero premature leakage without the pore capping, unlike mesoporous silica. MON were biocompatible and internalized into cancer cells for drug delivery.