Smart Hybrid Materials (SHMs)
مختبر شمس لعلوم النانو
Self-Assembled Nanomaterials for Biomedical, Sensing and Separation Applications

Publications 2019

Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent Xray-activated synergistic therapy

W. Fan, N. Lu, Z. Shen, W. Tang, B. Shen, (…), N.M. Khashab, M.A. Aronova, G. Lu, X. Chen. Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent Xray-activated synergistic therapy. Nature Communications, Volume 10, Article number: 1241, 2019
W. Fan, N. Lu, Z. Shen, W. Tang, B. Shen, (…), N.M. Khashab, M.A. Aronova, G. Lu, X. Chen
Mesoporous silica nanoparticle, Carbonyl iron, Drug delivery system, Synergistic therapy
2019
The success of radiotherapy relies on tumor-specific delivery of radiosensitizers to attenuate hypoxia resistance. Here we report an ammonia-assisted hot water etching strategy for the generic synthesis of a library of small-sized (sub-50 nm) hollow mesoporous organosilica nanoparticles (HMONs) with mono, double, triple, and even quadruple framework hybridization of diverse organic moieties by changing only the introduced bissilylated organosilica precursors. The biodegradable thioether-hybridized HMONs are chosen for efficient co-delivery of tert-butyl hydroperoxide (TBHP) and iron pentacarbonyl (Fe(CO)5). Distinct from conventional RT, radiodynamic therapy (RDT) is developed by taking advantage of X-ray-activated peroxy bond cleavage within TBHP to generate •OH, which can further attack Fe(CO)5 to release CO molecules for gas therapy. Detailed in vitro and in vivo studies reveal the X-ray-activated cascaded release of •OH and CO molecules from TBHP/Fe(CO)5 co-loaded PEGylated HMONs without reliance on oxygen, which brings about remarkable destructive effects against both normoxic and hypoxic cancers.