Smart Hybrid Materials (SHMs)
مختبر شمس لعلوم النانو
Self-Assembled Nanomaterials for Biomedical, Sensing and Separation Applications

Publications 2019

Synthetic vehicles for encapsulation and delivery of CRISPR/Cas9 gene editing machinery

V. Carboni,  C. Maaliki,  M. Alyami,  S. Alsaiari,  N. Khashab. Synthetic vehicles for encapsulation and delivery of CRISPR/Cas9 gene editing machinery. Advanced Therapeutics, Volume 2, Issue 4, 2019 ​
V. Carboni, C. Maaliki, M. Alyami, S. Alsaiari, N. Khashab.
CRISPR/Cas9 delivery, Gene editing, Hybrid materials, Nonviral vectors, Organic materials
2019
Clustered regularly interspaced short palindromic repeat (CRISPR) and CRISPR‐associated 9 (Cas‐9) technology holds tremendous potential as a gene editing tool. Different strategies have been adopted for in vitro and in vivo delivery of CRISPR/Cas9, including both viral and non‐viral. The possibility of tailoring properties of nanosized systems makes the molecular design of self‐assembled non‐viral delivery systems based on organic (lipids and polymers) and hybrid (zeolitic imidazolate frameworks, ZIF and gold nanoparticles) materials of a great interest in CRISPR/Cas9 delivery. This review highlights the progress and challenges of organic and hybrid CRISPR/Cas9 delivery vehicles.