Smart Hybrid Materials (SHMs)
Khashab Research Group
Innovatively Functionalized Nanomaterials for Biomedical, Sensing and Composites Applications

Publication-17

Snap-Top Nanocarriers

Ambrogio, M. W.; Pecorelli, T. A.; Patel, K.; Khashab, N. M.; Trabolsi, A.; Khatib, H. A.; Botros, Y. Y.; Zink, J. I.; Stoddart, J. F. Snap-Top Nanocarriers. Org. Lett. 2010, 12, 3304-3307
Ambrogio, M. W.; Pecorelli, T. A.; Patel, K.; Khashab, N. M.; Trabolsi, A.; Khatib, H. A.; Botros, Y. Y.; Zink, J. I.; Stoddart, J. F.
Snap-top, nanocarriers
2010
An approach to the design and fabrication of mechanized mesoporous silica nanoparticles is demonstrated at the proof of principle level. It relies on the reductive cleavage of disulfide bonds within an integrated nanosystem, wherein surface-bound rotaxanes incorporate disulfide bonds in their stalks,- which are encircled by cucurbit[6]uril or α-cyclodextrin rings, until reductive chem. is performed, resulting in the snapping of the stalks of the rotaxanes, leading to cargo release from the inside of the nanoparticles.