Smart Hybrid Materials (SHMs)
Khashab Research Group
Innovatively Functionalized Nanomaterials for Biomedical, Sensing and Composites Applications

Publication-2

The Preparation of 1,2,3-Trisubstituted Guanidines

Khashab, N. M.; Bobrov, S.; Katritzky, A. R. The Preparation of 1,2,3-Trisubstituted Guanidines. Helv. Chim. Acta 2005, 88, 1664-1675
Khashab, N. M.; Bobrov, S.; Katritzky, A. R.
1, 2, 3-Trisubstituted, guanidines
2005
An operationally straightforward and efficient benzotriazole-based method for the guanylation of diverse amines by use of the new reagent classes (bis-benzotriazol-1-yl-methylene)amines 13a13f and benzotriazole-1-carboxamidines 17a17i is described. The preparation is described for a variety of both acyclic and cyclic 1,2,3-trisubstituted guanidines in high yields.