Smart Hybrid Materials (SHMs)
Khashab Research Group
Innovatively Functionalized Nanomaterials for Biomedical, Sensing and Composites Applications

Publication-4

Synthesis of Mono- and Symmetrical Di-N-hydroxy- and N-Aminoguanidines

Khashab, N. M.; Bobrov, S.; Yoshioka, M.; Katritzky, A. R. Synthesis of Mono- and Symmetrical Di-N-hydroxy- and N-Aminoguanidines. J. Org. Chem. 2006, 71, 6753-6758

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Khashab, N. M.; Bobrov, S.; Yoshioka, M.; Katritzky, A. R.
Synthesis, mono-, symmetrical, di-N-hydroxy-, N-aminoguanidines
2006
Novel mono- and sym. di-N-hydroxy- and N-aminoguanidines were readily prepd. from the reaction of diverse hydroxylamines or hydrazines with di(benzotriazol-1-yl)methanimine, (bis-benzotriazol-1-yl-methylene)amines, benzotriazole-1-carboxamidines, benzotriazole-1-carboximidamides, and N'-hydroxy-1H-1,2,3-benzotriazole-1-carboximidamide. The prepn. is described for a variety of N-hydroxy- and N-aminoguanidines with different substitution patterns in good yields.