Microwave-Induced Chemotoxicity of Polydopamine-Coated Magnetic Nanocubes

by Julfakyan, K., Fatieiev, Y., ALsaiari, S., Deng, L., Ezzeddine, A., Zhang, D., Rotello, V.M., Khashab, N.M.
Year: 2015


Julfakyan, K.; Fatieiev, Y.; Alsaiari, S.; Deng, L.; Ezzeddine, A.; Zhang, D.; Rotello, V.M.; Khashab, N.M. Microwave-Induced Chemotoxicity of Polydopamine-Coated Magnetic Nanocubes. Int. J. Mol. Sci. 2015, 16, 18283-18292


Polydopamine-coated FeCo nanocubes (PDFCs) were successfully synthesized and tested under microwave irradiation of 2.45 GHz frequency and 0.86 W/cm2 power. These particles were found to be non-toxic in the absence of irradiation, but gained significant toxicity upon irradiation. Interestingly, no increase in relative heating rate was observed when the PDFCs were irradiated in solution, eliminating nanoparticle (NP)-induced thermal ablation as the source of toxicity. Based on these studies, we propose that microwave-induced redox processes generate the observed toxicity.

FeCo NPs


FeCo Nanocubes Polydopamine Microwave Radiation Nanomedicine