Post-synthetic infiltration of enzymes in hierarchical ZIF-8 for enhanced stability and activity retention
byShahad AlOtaiby, Lukman O. Alimi, Somayah Qutub, Ainur Sharip, Raik Grünberg, Batoul Maatouk, Stefan T. Arold, Niveen M. Khashab
Year:2026DOI:10.1039/d6cc03565e
Bibliography
Shahad Alotaiby, Lukman O Alimi, Somayah Qutub, Ainur Sharip, Raik Grünberg, Batoul Maatouk, Stefan T Arold, Niveen M Khashab. Post-synthetic infiltration of enzymes in hierarchical ZIF-8 for enhanced stability and activity retention. Chemical Communications, 2026.
Abstract
Herein, we report that the widely used one-pot in situ encapsulation of enzymes in ZIF-8 can inhibit enzyme activity due to precursor-induced toxicity. However, post-synthetic infiltration of the enzyme into hierarchical ZIF-8 prevents this deactivation, yielding superior enzyme stability and activity retention for efficient biocatalytic applications.
