The Preparation of 1,2,3-Trisubstituted Guanidines

by Khashab, N. M., Bobrov, S., Katritzky, A. R.
Year: 2005


Khashab, N. M.; Bobrov, S.; Katritzky, A. R. The Preparation of 1,2,3-Trisubstituted Guanidines. Helv. Chim. Acta 2005, 88, 1664-1675


An operationally straightforward and efficient benzotriazole-based method for the guanylation of diverse amines by use of the new reagent classes (bis-benzotriazol-1-yl-methylene)amines 13a–13f and benzotriazole-1-carboxamidines 17a–17i is described. The preparation is described for a variety of both acyclic and cyclic 1,2,3-trisubstituted guanidines in high yields.


1 2 3-Trisubstituted Guanidines