Synthesis of Mono- and Symmetrical Di-N-hydroxy- and N-Aminoguanidines

by Khashab, N. M., Bobrov, S., Yoshioka, M., Katritzky, A. R.
Year: 2006


Khashab, N. M.; Bobrov, S.; Yoshioka, M.; Katritzky, A. R. Synthesis of Mono- and Symmetrical Di-N-hydroxy- and N-Aminoguanidines. J. Org. Chem. 2006, 71, 6753-6758


Novel mono- and sym. di-N-hydroxy- and N-aminoguanidines were readily prepd. from the reaction of diverse hydroxylamines or hydrazines with di(benzotriazol-1-yl)methanimine, (bis-benzotriazol-1-yl-methylene)amines, benzotriazole-1-carboxamidines, benzotriazole-1-carboximidamides, and N'-hydroxy-1H-1,2,3-benzotriazole-1-carboximidamide. The prepn. is described for a variety of N-hydroxy- and N-aminoguanidines with different substitution patterns in good yields.


Synthesis mono- Symmetrical di-N-hydroxy- N-aminoguanidines